CONHIV14 - HIV-related Infections, Co-infections and Cancers, etc. – Part three - page 12

Ada WC LIN, Ka-hing WONG, Kenny CHAN
Special Preventive Programme, Centre for Health Protection, Department of Health, Hong Kong SAR, China
Methods
Baseline and annual testing of anti-HCV was in place for all HIV-
infected MSM in the largest HIV clinic in Hong Kong. Logistic
regression was used to compare those with HCV seroconversion
(seroconverters) with those remained tested anti-HCV negative
(non-seroconverters) to identify factors associated with incident
HCV.
Background
The epidemiology of hepatitis C virus (HCV) infections in Chinese
HIV-infected men who have sex with men (MSM) remains
obscure. More data is required to understand the epidemic and
set up preventive strategy.
Presented at HIV Drug Therapy Glasgow 2014
Conclusions
The incidence of HCV has been increasing among HIV
infected MSM non injecting drug users in Hong Kong. More
education and intervention on safer sex is required to target
on those with higher education level.
Correspondence: Dr Ada WC LIN
HCV seroconverters
(n=14)
HCV non-
seroconverters
(n=1297)
P value/
Odd Ratio
Median age (years)
38
40
0.55
Ethnicity
Chinese
14 (100%)
0
1126 (86.8%)
171 (13.2%)
0.99
Non-Chi ese
Education
level
Below secondary
or no school
2 (14.3%)
12 (85.7%)
639 (49.3%)
658 (50.7%)
0.02
1
5.28
Tertiary or above
Baseline median CD4 count
(ul
3
)
261
330
0.33
Baseline median HIV viral load
(copies/
3
)
93500
55000
0.50
On antiretroviral therapy
9 (64%)
833 (64.2%)
0.99
Median duration of antiretroviral
therapy (days)
317
479
0.96
Prior history of
sexually
transmitted infection
13 (92.9%)
790 (60.9%)
0.04
8.31
1
Prior history of syphilis
8 (57.1%)
482 (37.2%)
0.13
Results
From 1999 to 2013, 1,311 patients were tested for anti-HCV
seroconversion, contributing to 6,295 patient-years of
observation.
Fourteen (1.1%) patients seroconverted, with genotype 3 being
most commonly detected. The overall incidence rate of HCV
infection was 0.22 per 100 patient-years (PY) in the cohort. The
incidence rate increased from 0.13 per 100PY before 2002 to
0.19 per 100PY in 2002-2007 and 0.47 per 100PY in 2008-2013.
All the seroconverters were Chinese, with median age of anti-
HCV seroconversion at 38 years (range: 28 to 53 years). None
of them were injecting drug users.
Table. Comparison between HCV seroconverters and HCV non-seroconverters
Conclusions
The incidence of HCV has been increasing among HIV infected
MSM non injecting drug users in Hong Kong. More education and
intervention on safer sex is required to target on those with higher
education level.
Correspondence: Dr Ada WC LIN
0.13
0.19
0.47
0
0.1
0.2
0.3
0.4
0.5
Before 2002
2002-2007
2008-2013
R
a
t
e
p
e
r
1
0
0
P
Y
Years
Incidence of HCV infection
Results
As compared with the non-seroconverters, seroconverters were of
higher education level (85.7% vs 50.7% tertiary education or above,
OR 5.28, p=0.02) and had prior history of sexually transmitted
infection (92.9% vs 60.9%, OR 8.34, p=0.04). More seroconverters
were found to have history of syphilis infection (57.1% vs 37.2%,
p=0.13) but the difference was not statistically significant. Baseline
CD4 count and HIV viral load, proportion on antiretroviral therapy
and duration of antiretroviral therapy were not different between
two groups. Epidemiological investigation showed that none of the
cases had history of injecting drug use. Thirteen (76.5%) cases
reported unprotected anal and/or oral sex, and 3 (17.6%) cases
reported use of recreational drugs. There was however no
apparent linkage on their sexual exposure.
Abstract No: P131
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