Abbreviation SequenceDescription Organism size average size SD of size GI Group Kingdom TMSs SD of TMSs average TMSs average TMSs(Ave.Has) conservative domain
Cluster 1                          
Rsp1 hypothetical protein RAZWK3B_01100 Roseobacter sp. AzwK-3b 240 242.75 15.68211 149912542 Alphaproteobacteria Bacteria 8 0.5175492 7.625 8  
Dre1 protein of unknown function DUF81 Desulfotomaculum reducens MI-1 272     134300581 Firmicutes Bacteria 8       cl00498, DUF81, Domain of unknown function DUF81. This integral membrane protein family has no known...
Dha1 hypothetical protein DSY0404 Desulfitobacterium hafniense Y51 239     89893150 Firmicutes Bacteria 8        
Bsp2 membrane protein Bacillus sp. B14905 242     126649939 Firmicutes Bacteria 7       no conservative domain
Oih1 hypothetical protein OB0823 Oceanobacillus iheyensis HTE831 244     23098278 Firmicutes Bacteria 7       no conservative domain
Ban1 COG0730: Predicted permeases Bacillus anthracis str. A2012 214     65318985 Firmicutes Bacteria 7        
Msp9 hypothetical membrane protein Moritella sp. PE36 245     149908818 Gammaproteobacteria Bacteria 8       cl00498, DUF81, Domain of unknown function DUF81. This integral membrane protein family has no known...
Spe1 protein of unknown function DUF81 Shewanella pealeana ATCC 700345 246     157963974 Gammaproteobacteria Bacteria 8        
                           
Cluster 2                          
Oca4 putative protein of unknown function DUF81 Oligotropha carboxidovorans OM5 242 250.45161 9.120814 170790091 Alphaproteobacteria Bacteria 7 0.9694251 8.1613 8  
Rpa1 Protein of unknown function DUF81 Rhodopseudomonas palustris HaA2 255     86748610 Alphaproteobacteria Bacteria 7        
Mra1 protein of unknown function DUF81 Methylobacterium radiotolerans JCM 2831 251     170751140 Alphaproteobacteria Bacteria 7       no conservative domain
Rpa2 DUF81 Rhodopseudomonas palustris CGA009 262     39933191 Alphaproteobacteria Bacteria 8        
Rsp3 hypothetical protein R2601_05768 Roseovarius sp. HTCC2601 250     114763144 Alphaproteobacteria Bacteria 8        
Pde2 Protein of unknown function DUF81 Paracoccus denitrificans PD1222 245     69938224 Alphaproteobacteria Bacteria 9        
Cli2 conserved hypothetical protein, membrane Congregibacter litoralis KT71 255     88704216 Gammaproteobacteria Bacteria 8        
Orf11 hypothetical protein MGP2080_07137 marine gamma proteobacterium HTCC2080 256     119503062 Gammaproteobacteria Bacteria 8        
Rba5 hypothetical protein RB2150_04563 Rhodobacterales bacterium HTCC2150 249     126725447 Alphaproteobacteria Bacteria 8        
Msp5 protein of unknown function DUF81 Methylobacterium sp. 4-46 247     170740565 Alphaproteobacteria Bacteria 10       no conservative domain
Lag3 hypothetical protein SIAM614_23682 Labrenzia aggregata IAM 12614 253     118588336 Alphaproteobacteria Bacteria 8        
Bsp1 hypothetical protein BRADO0142 Bradyrhizobium sp. ORS278 263     146337311 Alphaproteobacteria Bacteria 9        
Rle1 putative transmembrane protein Rhizobium leguminosarum bv. viciae 3841 263     116251433 Alphaproteobacteria Bacteria 9        
Atu1 hypothetical protein Atu0761 Agrobacterium tumefaciens str. C58 239     159184454 Alphaproteobacteria Bacteria 9        
Msp2 hypothetical conserved membrane protein Marinobacter sp. ELB17 254     126665286 Gammaproteobacteria Bacteria 8        
Cps1 hypothetical protein CPS_3342 Colwellia psychrerythraea 34H 255     71279800 Gammaproteobacteria Bacteria 8        
Vsp2 hypothetical protein MED222_11713 Vibrio sp. MED222 245     86145078 Gammaproteobacteria Bacteria 8        
Rba7 hypothetical protein OM2255_05940 Rhodobacterales bacterium HTCC2255 250     114769248 Alphaproteobacteria Bacteria 9        
Rsp7 hypothetical protein RAZWK3B_11016 Roseobacter sp. AzwK-3b 257     149915707 Alphaproteobacteria Bacteria 7        
Pub1 hypothetical protein PU1002_06496 Candidatus Pelagibacter ubique HTCC1002 253     91762898 Alphaproteobacteria Bacteria 10       no conservative domain
Rsp4 hypothetical protein RCCS2_04744 Roseobacter sp. CCS2 254     126733434 Alphaproteobacteria Bacteria 8        
Rba8 hypothetical protein RB2150_15431 Rhodobacterales bacterium HTCC2150 252     126725240 Alphaproteobacteria Bacteria 8        
Pga1 hypothetical protein RG210_10322 Phaeobacter gallaeciensis 2.10 240     163740490 Alphaproteobacteria Bacteria 7        
Lve2 hypothetical protein SKA53_00599 Loktanella vestfoldensis SKA53 249     84516962 Alphaproteobacteria Bacteria 8        
Orf8 hypothetical protein BAL199_15107 alpha proteobacterium BAL199 226     163795458 Alphaproteobacteria Bacteria 6       no conservative domain
Ssp3 hypothetical protein NAS141_01131 Sulfitobacter sp. NAS-14.1 234     83956359 Alphaproteobacteria Bacteria 9        
Rsp16 hypothetical protein RHA1_ro03581 Rhodococcus sp. RHA1 251     111020570 Actinobacteria Bacteria 10        
Csa2 protein of unknown function DUF81 Chromohalobacter salexigens DSM 3043 250     92112295 Gammaproteobacteria Bacteria 9        
Pin1 hypothetical protein DUF81 Psychromonas ingrahamii 37 245     119943843 Gammaproteobacteria Bacteria 8        
Nca1 hypothetical protein MED92_13216 Neptuniibacter caesariensis 274     89093414 Gammaproteobacteria Bacteria 7        
Msp13 hypothetical protein MED121_06815 Marinomonas sp. MED121 245     87119630 Gammaproteobacteria Bacteria 8        
                           
Cluster 3                          
Rde1 hypothetical protein RD1_0836 Roseobacter denitrificans OCh 114 241 242 7.5150642 110678188 Alphaproteobacteria Bacteria 8 0.428932 7.7727 8  
Rsp2 hypothetical protein MED297_14675 Reinekea sp. MED297 237     88800269 Gammaproteobacteria Bacteria 8        
Ppr3 hypothetical protein PBPRA2468 Photobacterium profundum SS9 242     54309632 Gammaproteobacteria Bacteria 8        
Psp6 hypothetical protein SKA34_13600 Photobacterium sp. SKA34 239     89074261 Gammaproteobacteria Bacteria 7       cl00498, DUF81, Domain of unknown function DUF81. This integral membrane protein family has no known...
Vfi1 predicted permease Vibrio fischeri ES114 237     59711726 Gammaproteobacteria Bacteria 8        
Pin4 hypothetical protein DUF81 Psychromonas ingrahamii 37 242     119945499 Gammaproteobacteria Bacteria 7        
Sam2 protein of unknown function DUF81 Shewanella amazonensis SB2B 245     119776305 Gammaproteobacteria Bacteria 8        
Ssp6 protein of unknown function DUF81 Shewanella sp. MR-4 247     113971771 Gammaproteobacteria Bacteria 8        
Cef2 hypothetical protein CE1187 Corynebacterium efficiens YS-314 237     25027743 Actinobacteria Bacteria 8        
Lch1 protein of unknown function DUF81 Leptothrix cholodnii SP-6 251     171061013 Betaproteobacteria Bacteria 8        
Bli1 COG0730: Predicted permeases Brevibacterium linens BL2 236     62424535 Actinobacteria Bacteria 8        
Rsp14 hypothetical protein ROS217_12946 Roseovarius sp. 217 235     85703906 Alphaproteobacteria Bacteria 8        
Pde1 Protein of unknown function DUF81 Paracoccus denitrificans PD1222 236     69935354 Alphaproteobacteria Bacteria 8        
Sam1 putative permease Streptomyces ambofaciens ATCC 23877 236     126347823 Actinobacteria Bacteria 8        
Reu3 Protein of unknown function DUF81 Ralstonia eutropha JMP134 235     73538356 Betaproteobacteria Bacteria 7        
Orf5 hypothetical protein A20C1_08538 marine actinobacterium PHSC20C1 226     88854897 Actinobacteria Bacteria 7        
Mlu1 protein of unknown function DUF81 Micrococcus luteus NCTC 2665 255     177672905 Actinobacteria Bacteria 8        
Cef1 hypothetical protein CE0132 Corynebacterium efficiens YS-314 250     25026688 Actinobacteria Bacteria 8        
Cur1 hypothetical protein cu1151 Corynebacterium urealyticum DSM 7109 253     172040831 Actinobacteria Bacteria 8        
Cef3 hypothetical protein CE1442 Corynebacterium efficiens YS-314 247     25027998 Actinobacteria Bacteria 8        
Rsp10 possible permease Rhodococcus sp. RHA1 243     111020533 Actinobacteria Bacteria 7        
Rsp12 possible permease Rhodococcus sp. RHA1 254     111025621 Actinobacteria Bacteria 8        
                           
Cluster 4                          
Dal2 protein of unknown function DUF81 Desulfatibacillum alkenivorans AK-01 244 255 16.382918 163723410 Deltaproteobacteria Bacteria 8 0.8738629 7.78182 8  
Dvu1 hypothetical protein DVU2276 Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough 248     46580681 Deltaproteobacteria Bacteria 8        
Dps3 hypothetical protein DP1053 Desulfotalea psychrophila LSv54 250     51244905 Deltaproteobacteria Bacteria 7        
Dps2 hypothetical protein DP1701 Desulfotalea psychrophila LSv54 250     51245553 Deltaproteobacteria Bacteria 10       no conservative domain
Dvu2 hypothetical protein DVU1234 Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough 243     46579645 Deltaproteobacteria Bacteria 8        
Tca1 protein of unknown function DUF81 Thermosinus carboxydivorans Nor1 260     121533299 Firmicutes Bacteria 8        
Ame1 protein of unknown function DUF81 Alkaliphilus metalliredigens QYMF 244     150389367 Firmicutes Bacteria 7        
Psp3 protein of unknown function DUF81 Paenibacillus sp. JDR-2 242     169187862 Firmicutes Bacteria 8        
Pae1 hypothetical protein PAE2578 Pyrobaculum aerophilum str. IM2 288     18313446 Crenarchaeota Archaea 7        
Dha2 hypothetical protein DSY4979 Desulfitobacterium hafniense Y51 251     89897725 Firmicutes Bacteria 7        
Dps4 hypothetical protein DP1514 Desulfotalea psychrophila LSv54 285     51245366 Deltaproteobacteria Bacteria 8        
                           
Cluster 5                          
Ppr2 hypothetical membrane protein Photobacterium profundum 3TCK 247 248.41667 18.238114 90409668 Gammaproteobacteria Bacteria 7 0.492366 7.6667 8  
Eco1 hypothetical protein Z5415 Escherichia coli O157:H7 EDL933 291     15804464 Gammaproteobacteria Bacteria 8        
Csp1 putative permease Carnobacterium sp. AT7 249     163790059 Firmicutes Bacteria 8        
Ppe1 Predicted permease Pediococcus pentosaceus ATCC 25745 243     116491833 Firmicutes Bacteria 7        
Ssa1 putative permease Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 216     73661460 Firmicutes Bacteria 7        
Sau1 membrane protein Staphylococcus aureus 248     32470401 Firmicutes Bacteria 8        
Vsh1 hypothetical protein VSAK1_23649 Vibrio shilonii AK1 246     149187768 Gammaproteobacteria Bacteria 8        
Sfu1 protein of unknown function DUF81 Syntrophobacter fumaroxidans MPOB 240     116750354 Deltaproteobacteria Bacteria 8        
Csp3 protein of unknown function DUF81 Cyanothece sp. PCC 7424 248     186899192 Cyanobacteria Bacteria 8        
Csp4 hypothetical protein cce_3027 Cyanothece sp. ATCC 51142 242     172037940 Cyanobacteria Bacteria 8        
Pma1 hypothetical membrane protein Planctomyces maris DSM 8797 272     149174374 Planctomycetes Bacteria 7        
Orf3 protein of unknown function DUF81 bacterium Ellin514 239     186460272 Verrucomicrobia Bacteria 8        
                           
Cluster 6                          
Aba1 hypothetical protein ATW7_15999 Alteromonadales bacterium TW-7 244 246.26316 24.664059 119469728 Gammaproteobacteria Bacteria 7 0.9015905 7.5789 8  
Ama4 hypothetical protein MADE_06320 Alteromonas macleodii 'Deep ecotype' 250     88796386 Gammaproteobacteria Bacteria 8        
Orf4 hypothetical protein GP2143_09350 marine gamma proteobacterium HTCC2143 248     119477657 Gammaproteobacteria Bacteria 8        
Msp11 hypothetical protein PE36_09621 Moritella sp. PE36 167     149909261 Gammaproteobacteria Bacteria 5       no conservative domain
Bph1 protein of unknown function DUF81 Burkholderia phymatum STM815 253     186470980 Betaproteobacteria Bacteria 8        
Bxe2 hypothetical protein Bxe_B0689 Burkholderia xenovorans LB400 253     91779406 Betaproteobacteria Bacteria 8        
Reu2 Protein of unknown function DUF81 Ralstonia eutropha JMP134 256     73537606 Betaproteobacteria Bacteria 8        
Bsp6 protein of unknown function DUF81 Burkholderia sp. 383 255     78062844 Betaproteobacteria Bacteria 8        
Ppr5 hypothetical protein P3TCK_09353 Photobacterium profundum 3TCK 200     90412229 Gammaproteobacteria Bacteria 6       no conservative domain
Vsp5 hypothetical protein MED222_09003 Vibrio sp. MED222 254     86144536 Gammaproteobacteria Bacteria 8        
Hch2 protein of unknown function, DUF81 family Hahella chejuensis KCTC 2396 252     83649281 Gammaproteobacteria Bacteria 8        
Epe1 hypothetical protein Epers_00660 Endoriftia persephone 'Hot96_1+Hot96_2' 247     167945085 Gammaproteobacteria Bacteria 8        
Msp3 protein of unknown function DUF81 Marinomonas sp. MWYL1 250     152994558 Gammaproteobacteria Bacteria 7        
Msp14 hypothetical protein MED121_10010 Marinomonas sp. MED121 250     87120935 Gammaproteobacteria Bacteria 8        
Bpa2 putative integral membrane protein Bordetella parapertussis 12822 256     33596999 Betaproteobacteria Bacteria 7        
Cte1 putative integral membrane protein Comamonas testosteroni KF-1 278     118051534 Betaproteobacteria Bacteria 9        
Dac1 putative integral membrane protein Delftia acidovorans SPH-1 278     160896385 Betaproteobacteria Bacteria 8        
Bha1 hypothetical protein BH2939 Bacillus halodurans C-125 245     15615501 Firmicutes Bacteria 8        
Gth1 hypothetical protein GTNG_0343 Geobacillus thermodenitrificans NG80-2 243     138894017 Firmicutes Bacteria 7        
                           
Cluster 7                          
Bja1 hypothetical protein blr3870 Bradyrhizobium japonicum USDA 110 242 252.35294 13.619569 27378981 Alphaproteobacteria Bacteria 7 0.4696682 7.7059 8  
Rpa5 DUF81 Rhodopseudomonas palustris CGA009 247     39934768 Alphaproteobacteria Bacteria 8        
Orf9 hypothetical protein BAL199_01839 alpha proteobacterium BAL199 247     163794115 Alphaproteobacteria Bacteria 7       no conservative domain
Bpe2 hypothetical protein Bpet0407 Bordetella petrii DSM 12804 247     163854712 Betaproteobacteria Bacteria 7        
Oca2 putative domain of unknown function Oligotropha carboxidovorans OM5 249     170788768 Alphaproteobacteria Bacteria 8        
Mra2 protein of unknown function DUF81 Methylobacterium radiotolerans JCM 2831 270     170750725 Alphaproteobacteria Bacteria 8        
Bpa1 putative inner membrane protein Bordetella parapertussis 12822 247     33596412 Betaproteobacteria Bacteria 8        
Reu4 Protein of unknown function DUF81 Ralstonia eutropha JMP134 250     73538113 Betaproteobacteria Bacteria 8        
Avi1 Protein of unknown function DUF81 Azotobacter vinelandii AvOP 300     67159159 Gammaproteobacteria Bacteria 8        
Har2 hypothetical protein HEAR3325 Herminiimonas arsenicoxydans 245     134096477 Betaproteobacteria Bacteria 8       no conservative domain
Orf2 predicted membrane protein uncultured bacterium BAC17H8 249     68164591 none Bacteria 8        
Orf6 membrane protein uncultured marine bacterium HF10_25F10 248     119094180 none Bacteria 7        
Rsp8 hypothetical membrane protein Rhodobacter sphaeroides 2.4.1 253     77465171 Alphaproteobacteria Bacteria 7        
Jsp1 protein of unknown function DUF81 Jannaschia sp. CCS1 250     89056463 Alphaproteobacteria Bacteria 8        
Rnu2 hypothetical membrane protein Roseovarius nubinhibens ISM 252     83951338 Alphaproteobacteria Bacteria 8        
Rli1 integral membrane protein, putative Roseobacter litoralis Och 149 247     163731466 Alphaproteobacteria Bacteria 8        
Rsp17 hypothetical membrane protein Roseovarius sp. 217 247     85706038 Alphaproteobacteria Bacteria 8        
                           
Cluster 8                          
Mpe1 hypothetical protein Mpe_A2576 Methylibium petroleiphilum PM1 258 257.13043 15.351353 124267760 Betaproteobacteria Bacteria 8 0.7331776 7.913 8  
Bsp7 protein of unknown function DUF81 Burkholderia sp. 383 267     78062087 Betaproteobacteria Bacteria 9        
Vsp1 hypothetical protein VspiD_23195 Verrucomicrobium spinosum DSM 4136 253     171914136 Verrucomicrobia Bacteria 8       cl00498, DUF81, Domain of unknown function DUF81. This integral membrane protein family has no known...
Bpe4 hypothetical protein Bpet1871 Bordetella petrii DSM 12804 252     163856181 Betaproteobacteria Bacteria 7        
Reu1 Protein of unknown function DUF81 Ralstonia eutropha JMP134 249     73541323 Betaproteobacteria Bacteria 8        
Atu3 hypothetical protein Atu2316 Agrobacterium tumefaciens str. C58 223     159185156 Alphaproteobacteria Bacteria 7        
Lsp3 hypothetical protein LMED105_09417 Limnobacter sp. MED105 250     149927063 Betaproteobacteria Bacteria 8        
Oca1 protein of unknown function DUF81 Oligotropha carboxidovorans OM5 263     170788274 Alphaproteobacteria Bacteria 8        
Bsp4 hypothetical protein BRADO6218 Bradyrhizobium sp. ORS278 257     146343030 Alphaproteobacteria Bacteria 7       cl00498, DUF81, Domain of unknown function DUF81. This integral membrane protein family has no known...
Rpa4 DUF81 Rhodopseudomonas palustris CGA009 255     39933978 Alphaproteobacteria Bacteria 8        
Rba6 membrane protein, putative Rhodobacterales bacterium HTCC2654 258     84683947 Alphaproteobacteria Bacteria 8        
Ssp1 membrane protein, putative Sulfitobacter sp. EE-36 255     83941544 Alphaproteobacteria Bacteria 8        
Rsp5 hypothetical protein ROS217_04380 Roseovarius sp. 217 257     85705117 Alphaproteobacteria Bacteria 8        
Oba2 hypothetical protein OB2597_10184 Oceanicola batsensis HTCC2597 256     84500303 Alphaproteobacteria Bacteria 8        
Sst2 hypothetical protein SSE37_20232 Sagittula stellata E-37 256     126728355 Alphaproteobacteria Bacteria 7        
Ssp4 protein of unknown function DUF81 Silicibacter sp. TM1040 255     99082285 Alphaproteobacteria Bacteria 8        
Pga2 hypothetical protein RG210_08787 Phaeobacter gallaeciensis 2.10 284     163740183 Alphaproteobacteria Bacteria 9       no conservative domain
Lve1 membrane protein, putative Loktanella vestfoldensis SKA53 256     84515168 Alphaproteobacteria Bacteria 7       no conservative domain
Rba9 hypothetical protein OM2255_01167 Rhodobacterales bacterium HTCC2255 259     114771363 Alphaproteobacteria Bacteria 8        
Rde3 hypothetical protein RD1_1107 Roseobacter denitrificans OCh 114 249     110678442 Alphaproteobacteria Bacteria 8        
Rba11 hypothetical protein RB2150_12731 Rhodobacterales bacterium HTCC2150 247     126724700 Alphaproteobacteria Bacteria 8        
Rba10 glutamine amidotransferase Rhodobacterales bacterium HTCC2654 246     84684823 Alphaproteobacteria Bacteria 7        
Bce1 protein of unknown function DUF81 Burkholderia cenocepacia MC0-3 309     170737004 Betaproteobacteria Bacteria 10       cl00498, DUF81, Domain of unknown function DUF81. This integral membrane protein family has no known...
                           
Cluster 9                          
Cbe1 protein of unknown function DUF81 Clostridium beijerinckii NCIMB 8052 243 247.81481 9.7784576 150018764 Firmicutes Bacteria 7 0.5547002 7.3333 8  
Cbu1 putative domain of unknown function Clostridium butyricum 5521 237     182418741 Firmicutes Bacteria 7        
Esp1 hypothetical protein Epulo_03277 Epulopiscium sp. 'N.t. morphotype B' 243     168333909 Firmicutes Bacteria 8        
Dal3 protein of unknown function DUF81 Desulfatibacillum alkenivorans AK-01 249     163723395 Deltaproteobacteria Bacteria 7        
Dal1 protein of unknown function DUF81 Desulfatibacillum alkenivorans AK-01 247     163724776 Deltaproteobacteria Bacteria 7       no conservative domain
Osp1 hypothetical protein RED65_15533 Oceanobacter sp. RED65 247     94500495 Gammaproteobacteria Bacteria 7        
Rsp11 Predicted permease Reinekea sp. MED297 241     88797883 Gammaproteobacteria Bacteria 8       cl00498, DUF81, Domain of unknown function DUF81. This integral membrane protein family has no known… (CDD; a bit cut off at the left end)
Pto1 hypothetical protein P700755_11902 Psychroflexus torquis ATCC 700755 238     91214996 Bacteroidetes Bacteria 8        
Pir1 predicted Permease Polaribacter irgensii 23-P 263     88803824 Bacteroidetes Bacteria 7        
Gfo1 membrane protein containing DUF81 Gramella forsetii KT0803 237     120434413 Bacteroidetes Bacteria 7        
Hsp1 protein of unknown function DUF81 Hydrogenobaculum sp. Y04AAS1 252     156719457 Aquificae Bacteria 7        
Ilo3 Predicted permease Idiomarina loihiensis L2TR 240     56459863 Gammaproteobacteria Bacteria 8        
Iba3 Predicted permease Idiomarina baltica OS145 242     85712128 Gammaproteobacteria Bacteria 8       cl00498, DUF81, Domain of unknown function DUF81. This integral membrane protein family has no known...
Vei1 protein of unknown function DUF81 Verminephrobacter eiseniae EF01-2 245     121609461 Betaproteobacteria Bacteria 7        
Dar1 Protein of unknown function DUF81 Dechloromonas aromatica RCB 254     71909525 Betaproteobacteria Bacteria 7        
Ppu1 protein of unknown function DUF81 Pseudomonas putida GB-1 251     167032042 Gammaproteobacteria Bacteria 8        
Orf7 PA3775 synthetic construct 261     49083038 none Unclassified 7        
Rme1 protein of unknown function DUF81 Ralstonia metallidurans CH34 284     94310878 Betaproteobacteria Bacteria 8        
Vei2 protein of unknown function DUF81 Verminephrobacter eiseniae EF01-2 251     121609161 Betaproteobacteria Bacteria 7       cl00498, DUF81, Domain of unknown function DUF81. This integral membrane protein family has no known...
Yin1 COG0730: Predicted permeases Yersinia intermedia ATCC 29909 249     77976482 Gammaproteobacteria Bacteria 7        
Spr1 protein of unknown function DUF81 Serratia proteamaculans 568 248     157368549 Gammaproteobacteria Bacteria 8        
Plu1 hypothetical protein plu4425 Photorhabdus luminescens subsp. laumondii TTO1 250     37528253 Gammaproteobacteria Bacteria 7        
Pst1 hypothetical protein PROSTU_00537 Providencia stuartii ATCC 25827 250     183597290 Gammaproteobacteria Bacteria 8        
Oca3 putative domain of unknown function Oligotropha carboxidovorans OM5 244     170790264 Alphaproteobacteria Bacteria 8        
Tde1 hypothetical protein Tbd_2380 Thiobacillus denitrificans ATCC 25259 240     74318398 Betaproteobacteria Bacteria 7        
Cte2 putative inner membrane protein TsaS Comamonas testosteroni 239     50727965 Betaproteobacteria Bacteria 6       no conservative domain
Bbr1 hypothetical protein BB0987 Bordetella bronchiseptica RB50 246     33599975 Betaproteobacteria Bacteria 7        
                           
Cluster 10                          
Msp4 hypothetical protein MELB17_06414 Marinobacter sp. ELB17 298     126666850 Gammaproteobacteria Bacteria 7     8  
                           
Cluster 11                          
Sth1 hypothetical protein STH1650 Symbiobacterium thermophilum IAM 14863 242     51892788 Firmicutes Bacteria 8     9  
                           
Cluster 12                          
Bsp5 protein of unknown function DUF81 Burkholderia sp. 383 260     78060822 Betaproteobacteria Bacteria 8     8  
                           
Cluster 13                          
Asp1 hypothetical protein azo3640 Azoarcus sp. BH72 255 251.81967 9.2367169 119899929 Betaproteobacteria Bacteria 7 0.624631 7.9016 8  
Xau1 protein of unknown function DUF81 Xanthobacter autotrophicus Py2 250     154244604 Alphaproteobacteria Bacteria 7        
Cli1 integral membrane protein (DUF81) Congregibacter litoralis KT71 250     88703534 Gammaproteobacteria Bacteria 8        
Oan1 protein of unknown function DUF81 Ochrobactrum anthropi ATCC 49188 282     153011095 Alphaproteobacteria Bacteria 8        
Rsp15 putative integral membrane protein Rhodobacter sphaeroides 2.4.1 245     77464549 Alphaproteobacteria Bacteria 8        
Rpa3 possible integral membrane protein Rhodopseudomonas palustris CGA009 254     39934087 Alphaproteobacteria Bacteria 8        
Atu2 hypothetical protein Atu3751 Agrobacterium tumefaciens str. C58 254     15891198 Alphaproteobacteria Bacteria 7        
Ret1 putative transporter, permease protein Rhizobium etli CFN 42 254     86359119 Alphaproteobacteria Bacteria 8        
Sme2 hypothetical protein SMc03997 Sinorhizobium meliloti 1021 260     15966534 Alphaproteobacteria Bacteria 8        
Mlo1 putative integral membrane protein Mesorhizobium loti MAFF303099 256     13473346 Alphaproteobacteria Bacteria 8        
Hph1 hypothetical protein HPDFL43_15507 Hoeflea phototrophica DFL-43 259     163758843 Alphaproteobacteria Bacteria 8        
Msp16 protein of unknown function DUF81 Mesorhizobium sp. BNC1 257     110635510 Alphaproteobacteria Bacteria 9        
Lag1 putative integral membrane protein Labrenzia aggregata IAM 12614 254     118588370 Alphaproteobacteria Bacteria 8        
Fpe2 putative integral membrane protein Fulvimarina pelagi HTCC2506 266     114705533 Alphaproteobacteria Bacteria 8        
Rsp18 hypothetical protein R2601_01573 Roseovarius sp. HTCC2601 256     114764374 Alphaproteobacteria Bacteria 7        
Sal1 protein of unknown function DUF81 Sphingopyxis alaskensis RB2256 252     103487858 Alphaproteobacteria Bacteria 8        
Nar1 protein of unknown function DUF81 Novosphingobium aromaticivorans DSM 12444 250     87199848 Alphaproteobacteria Bacteria 8        
Ssp5 hypothetical protein SKA58_11068 Sphingomonas sp. SKA58 252     94498689 Alphaproteobacteria Bacteria 8        
Swi1 protein of unknown function DUF81 Sphingomonas wittichii RW1 259     148555685 Alphaproteobacteria Bacteria 7        
Ppr1 putative integral membrane protein Photobacterium profundum 3TCK 252     90412374 Gammaproteobacteria Bacteria 9       cl00498, DUF81, Domain of unknown function DUF81. This integral membrane protein family has no known… (CDD; a bit cut off at the left end)
Vsh2 hypothetical protein VSAK1_25130 Vibrio shilonii AK1 253     149188770 Gammaproteobacteria Bacteria 7       cl00498, DUF81, Domain of unknown function DUF81. This integral membrane protein family has no known...
Rsp13 putative integral membrane protein Reinekea sp. MED297 254     88797379 Gammaproteobacteria Bacteria 8        
Msp15 protein of unknown function DUF81 Marinomonas sp. MWYL1 249     152996650 Gammaproteobacteria Bacteria 8       cl00498, DUF81, Domain of unknown function DUF81. This integral membrane protein family has no known...
Pme1 protein of unknown function DUF81 Pseudomonas mendocina ymp 244     146308194 Gammaproteobacteria Bacteria 8        
Lch2 protein of unknown function DUF81 Leptothrix cholodnii SP-6 252     171057976 Betaproteobacteria Bacteria 8        
Mpe2 putative integral membrane protein Methylibium petroleiphilum PM1 255     124266291 Betaproteobacteria Bacteria 7        
Psp5 protein of unknown function DUF81 Polaromonas sp. JS666 251     91787131 Betaproteobacteria Bacteria 8        
Pha1 hypothetical protein PSHAa1752 Pseudoalteromonas haloplanktis TAC125 243     77360692 Gammaproteobacteria Bacteria 8        
Ssp2 protein of unknown function DUF81 Shewanella sp. MR-4 245     113968405 Gammaproteobacteria Bacteria 8        
Osp2 hypothetical protein RED65_13037 Oceanobacter sp. RED65 243     94501545 Gammaproteobacteria Bacteria 8        
Rba4 putative integral membrane protein Rhodobacterales bacterium HTCC2255 254     114769908 Alphaproteobacteria Bacteria 9        
Psp1 protein of unknown function DUF81 Polynucleobacter sp. QLW-P1DMWA-1 261     145588717 Betaproteobacteria Bacteria 7        
Rnu1 membrane protein, putative Roseovarius nubinhibens ISM 248     83950438 Alphaproteobacteria Bacteria 8        
Rba1 hypothetical protein RB2150_14621 Rhodobacterales bacterium HTCC2150 249     126725078 Alphaproteobacteria Bacteria 8        
Ogr1 membrane protein, putative Oceanicola granulosus HTCC2516 250     89068129 Alphaproteobacteria Bacteria 9        
Lve3 membrane protein, putative Loktanella vestfoldensis SKA53 251     84515877 Alphaproteobacteria Bacteria 8        
Pga3 hypothetical protein RG210_04630 Phaeobacter gallaeciensis 2.10 251     163741825 Alphaproteobacteria Bacteria 7        
Rsp6 hypothetical protein RAZWK3B_04040 Roseobacter sp. AzwK-3b 251     149913130 Alphaproteobacteria Bacteria 8        
Rsp9 membrane protein, putative Roseovarius sp. 217 248     85704791 Alphaproteobacteria Bacteria 8        
Spo1 hypothetical protein SPO0350 Silicibacter pomeroyi DSS-3 251     56695265 Alphaproteobacteria Bacteria 8        
Rde2 integral membrane protein, putative Roseobacter denitrificans OCh 114 251     110678924 Alphaproteobacteria Bacteria 8        
Rba3 membrane protein, putative Rhodobacterales bacterium HTCC2654 250     84684229 Alphaproteobacteria Bacteria 8        
Sst3 hypothetical protein SSE37_11284 Sagittula stellata E-37 250     126730335 Alphaproteobacteria Bacteria 8        
Hch4 predicted Permease Hahella chejuensis KCTC 2396 247     83649504 Gammaproteobacteria Bacteria 8        
Sgr1 putative integral membrane protein Streptomyces griseus subsp. griseus NBRC 13350 277     182434674 Actinobacteria Bacteria 7        
Sco1 integral membrane protein Streptomyces coelicolor A3(2) 257     21225256 Actinobacteria Bacteria 6       cl00498, DUF81, Domain of unknown function DUF81. This integral membrane protein family has no known...
Dha3 hypothetical protein DSY3674 Desulfitobacterium hafniense Y51 256     89896420 Firmicutes Bacteria 8        
Pat1 protein of unknown function DUF81 Pseudoalteromonas atlantica T6c 250     109899288 Gammaproteobacteria Bacteria 8        
Fba2 hypothetical protein FB2170_06225 Flavobacteriales bacterium HTCC2170 210     88711689 Bacteroidetes Bacteria 7        
Asp2 hypothetical protein ALPR1_12185 Algoriphagus sp. PR1 251     126645401 Bacteroidetes Bacteria 8        
Oih2 hypothetical protein OB0991 Oceanobacillus iheyensis HTE831 248     23098446 Firmicutes Bacteria 10       cl00498, DUF81, Domain of unknown function DUF81. This integral membrane protein family has no known...
Bse1 Uncharacterized protein UPF0065 Bacillus selenitireducens MLS10 244     163764410 Firmicutes Bacteria 8        
Vva1 protein of unknown function DUF81 Victivallis vadensis ATCC BAA-548 251     150387340 Lentisphaerae Bacteria 8        
Lar1 hypothetical protein LNTAR_19902 Lentisphaera araneosa HTCC2155 257     149198963 Lentisphaerae Bacteria 8       cl00498, DUF81, Domain of unknown function DUF81. This integral membrane protein family has no known...
Rba2 putative integral membrane protein Rhodopirellula baltica SH 1 249     32475896 Planctomycetes Bacteria 9        
Vsp3 putative integral membrane protein Verrucomicrobium spinosum DSM 4136 255     171914845 Verrucomicrobia Bacteria 8        
Msp10 hypothetical protein MED121_14944 Marinomonas sp. MED121 240     87118334 Gammaproteobacteria Bacteria 8        
Msp8 protein of unknown function DUF81 Marinomonas sp. MWYL1 240     152994221 Gammaproteobacteria Bacteria 8        
Hch3 predicted Permease Hahella chejuensis KCTC 2396 243     83644471 Gammaproteobacteria Bacteria 8        
Sst1 hypothetical protein SSE37_23084 Sagittula stellata E-37 269     126729135 Alphaproteobacteria Bacteria 8        
Oba1 hypothetical membrane protein Oceanicola batsensis HTCC2597 246     84499517 Alphaproteobacteria Bacteria 8        
                           
Cluster 14                          
Csa1 protein of unknown function DUF81 Chromohalobacter salexigens DSM 3043 244 258.42308 40.347662 92112961 Gammaproteobacteria Bacteria 6 0.8124038 6.5 7  
Kst1 conserved hypothetical protein Candidatus Kuenenia stuttgartiensis 238     91203043 Planctomycetes Bacteria 7        
Bxe1 hypothetical protein Bxe_C0070 Burkholderia xenovorans LB400 227     91780140 Betaproteobacteria Bacteria 6       cl00498, DUF81, Domain of unknown function DUF81. This integral membrane protein family has no known...
Bsp3 hypothetical protein BRADO3283 Bradyrhizobium sp. ORS278 254     146340262 Alphaproteobacteria Bacteria 7        
Neu1 protein of unknown function DUF81 Nitrosomonas eutropha C91 352     114330399 Betaproteobacteria Bacteria 7        
Bin1 protein of unknown function DUF81 Beijerinckia indica subsp. indica ATCC 9039 343     182679111 Alphaproteobacteria Bacteria 7        
Mfl1 protein of unknown function DUF81 Methylobacillus flagellatus KT 344     91775905 Betaproteobacteria Bacteria 7        
Nwi1 Protein of unknown function DUF81 Nitrobacter winogradskyi Nb-255 346     75676620 Alphaproteobacteria Bacteria 7        
Ama2 hypothetical protein AM1_4804 Acaryochloris marina MBIC11017 246     158337917 Cyanobacteria Bacteria 8       cl00498, DUF81, Domain of unknown function DUF81. This integral membrane protein family has no known...
Mae1 unnamed protein product Microcystis aeruginosa PCC 7806 245     159030537 Cyanobacteria Bacteria 6        
Ter1 protein of unknown function DUF81 Trichodesmium erythraeum IMS101 248     113475725 Cyanobacteria Bacteria 6        
Psp2 hypothetical protein PsycPRwf_0733 Psychrobacter sp. PRwf-1 220     148652543 Gammaproteobacteria Bacteria 5       cl00498, DUF81, Domain of unknown function DUF81. This integral membrane protein family has no known…
Sme1 hypothetical membrane protein Sinorhizobium meliloti 1021 252     16263852 Alphaproteobacteria Bacteria 7        
Van1 putative membrane protein Vibrio angustum S14 223     90577398 Gammaproteobacteria Bacteria 6        
Bpe3 predicted permease Bordetella petrii DSM 12804 250     163854421 Betaproteobacteria Bacteria 6        
Hph2 hypothetical protein HPDFL43_19117 Hoeflea phototrophica DFL-43 245     163757552 Alphaproteobacteria Bacteria 7        
Fpe1 Predicted permease Fulvimarina pelagi HTCC2506 244     114705624 Alphaproteobacteria Bacteria 6        
Asp5 conserved hypothetical membrane protein Aurantimonas sp. SI85-9A1 252     90420735 Alphaproteobacteria Bacteria 7        
Iba1 Predicted permease Idiomarina baltica OS145 241     85711903 Gammaproteobacteria Bacteria 6        
Ilo2 Predicted permease Idiomarina loihiensis L2TR 252     56461450 Gammaproteobacteria Bacteria 7        
Sba1 protein of unknown function DUF81 Shewanella baltica OS195 252     160875419 Gammaproteobacteria Bacteria 6        
Msp6 Predicted permease Marinobacter sp. ELB17 254     126665494 Gammaproteobacteria Bacteria 7        
Maq1 permease Marinobacter aquaeolei VT8 197     120553131 Gammaproteobacteria Bacteria 4       no conservative domain
Pat2 protein of unknown function DUF81 Pseudoalteromonas atlantica T6c 246     109900403 Gammaproteobacteria Bacteria 7        
Ama3 putative orphan protein; putative membrane protein Alteromonas macleodii 'Deep ecotype' 256     88793145 Gammaproteobacteria Bacteria 7        
Nca3 putative membrane protein Neptuniibacter caesariensis 248     89091888 Gammaproteobacteria Bacteria 7        
                           
Cluster 15                          
Mac1 hypothetical protein MA1331 Methanosarcina acetivorans C2A 243 266.67241 10.55793 20090192 Euryarchaeota Archaea 8 0.7849538 7.7414 8  
Fba1 hypothetical transmembrane protein Flavobacteria bacterium BBFL7 245     89891000 Bacteroidetes Bacteria 7        
Fba3 hypothetical protein FB2170_09461 Flavobacteriales bacterium HTCC2170 232     88712855 Bacteroidetes Bacteria 6       no conservative domain
Lbl1 hypothetical protein MED217_15220 Leeuwenhoekiella blandensis MED217 244     86140514 Bacteroidetes Bacteria 8        
Hsp2 hypothetical protein HG1285_03613 Hydrogenivirga sp. 128-5-R1-1 246     163781939 Aquificae Bacteria 7        
Aae1 hypothetical protein aq_127 Aquifex aeolicus VF5 272     15605710 Aquificae Bacteria 8        
Nme1 Tou2 Neisseria meningitidis 255     6449092 Betaproteobacteria Bacteria 8        
Avi2 Protein of unknown function DUF81 Azotobacter vinelandii AvOP 267     67154977 Gammaproteobacteria Bacteria 8        
Dno1 hypothetical protein DNO_0075 Dichelobacter nodosus VCS1703A 265     146329858 Gammaproteobacteria Bacteria 8        
Har1 conserved hypothetical protein; putative membrane protein. Putative conserved domain: IPR002781 (Protein of unknown function DUF81) Herminiimonas arsenicoxydans 287     134096092 Betaproteobacteria Bacteria 10       cl00498, DUF81, Domain of unknown function DUF81. This integral membrane protein family has no known...
Lsp2 hypothetical protein LMED105_04832 Limnobacter sp. MED105 278     149925520 Betaproteobacteria Bacteria 9        
Dar2 Protein of unknown function DUF81 Dechloromonas aromatica RCB 266     71909635 Betaproteobacteria Bacteria 7        
Mfl2 protein of unknown function DUF81 Methylobacillus flagellatus KT 263     91776589 Betaproteobacteria Bacteria 8        
Orf1 Protein of unknown function DUF81 delta proteobacterium MLMS-1 265     94264877 Deltaproteobacteria Bacteria 8        
Dde1 hypothetical protein Dde_0751 Desulfovibrio desulfuricans subsp. desulfuricans str. G20 265     78355798 Deltaproteobacteria Bacteria 8        
Gme1 protein of unknown function DUF81 Geobacter metallireducens GS-15 263     78222746 Deltaproteobacteria Bacteria 7        
Dps1 hypothetical protein DP0383 Desulfotalea psychrophila LSv54 262     51244235 Deltaproteobacteria Bacteria 9        
Ppr4 protein of unknown function DUF81 Pelobacter propionicus DSM 2379 264     118579808 Deltaproteobacteria Bacteria 7        
Dvu3 hypothetical protein DVU2783 Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough 266     46581187 Deltaproteobacteria Bacteria 7        
Dar3 Protein of unknown function DUF81 Dechloromonas aromatica RCB 269     71909623 Betaproteobacteria Bacteria 8        
Nmu1 Protein of unknown function DUF81 Nitrosospira multiformis ATCC 25196 265     82701746 Betaproteobacteria Bacteria 8        
Asp3 hypothetical protein azo0636 Azoarcus sp. BH72 268     119896927 Betaproteobacteria Bacteria 8        
Asp4 hypothetical protein ebA1817 Azoarcus sp. EbN1 268     56476420 Betaproteobacteria Bacteria 8        
Psp4 protein of unknown function DUF81 Polynucleobacter sp. QLW-P1DMWA-1 272     145588817 Betaproteobacteria Bacteria 8        
Lsp1 hypothetical protein LMED105_01763 Limnobacter sp. MED105 289     149926219 Betaproteobacteria Bacteria 10       cl00498, DUF81, Domain of unknown function DUF81. This integral membrane protein family has no known...
Bpe1 putative integral membrane protein Bordetella pertussis Tohama I 272     33593832 Betaproteobacteria Bacteria 8        
Pna1 protein of unknown function DUF81 Polaromonas naphthalenivorans CJ2 271     121605270 Betaproteobacteria Bacteria 7        
Mpe3 putative integral membrane protein Methylibium petroleiphilum PM1 282     124267499 Betaproteobacteria Bacteria 7        
Pin3 hypothetical protein DUF81 Psychromonas ingrahamii 37 267     119947276 Gammaproteobacteria Bacteria 8        
Swo1 protein of unknown function DUF81 Shewanella woodyi ATCC 51908 268     170728324 Gammaproteobacteria Bacteria 8        
Nmo1 predicted Permease Nitrococcus mobilis Nb-231 266     88811005 Gammaproteobacteria Bacteria 8        
Mca1 hypothetical protein MCA0023 Methylococcus capsulatus str. Bath 294     53802665 Gammaproteobacteria Bacteria 6       cl00498, DUF81, Domain of unknown function DUF81. This integral membrane protein family has no known...
Abo1 hypothetical protein ABO_2346 Alcanivorax borkumensis SK2 269     110835207 Gammaproteobacteria Bacteria 8        
Osp3 predicted Permease Oceanobacter sp. RED65 263     94501824 Gammaproteobacteria Bacteria 7        
Msp1 hypothetical protein PE36_07941 Moritella sp. PE36 261     149911651 Gammaproteobacteria Bacteria 8        
Ahy1 hypothetical protein AHA_2086 Aeromonas hydrophila subsp. hydrophila ATCC 7966 262     117619625 Gammaproteobacteria Bacteria 7        
Hch1 predicted Permease Hahella chejuensis KCTC 2396 266     83648499 Gammaproteobacteria Bacteria 7        
Nca2 hypothetical protein MED92_04594 Neptuniibacter caesariensis 266     89093747 Gammaproteobacteria Bacteria 7        
Orf10 PA0340 synthetic construct 268     49082896 none Unclassified 8        
Msp7 hypothetical protein MELB17_19204 Marinobacter sp. ELB17 265     126665227 Gammaproteobacteria Bacteria 8        
Par1 probable integral membrane protein, DUF81 family Psychrobacter arcticus 273-4 268     71065697 Gammaproteobacteria Bacteria 7        
Pir2 hypothetical protein PI23P_10877 Polaribacter irgensii 23-P 281     88803086 Bacteroidetes Bacteria 7        
Par2 probable transmembrane protein Psychrobacter arcticus 273-4 274     71065408 Gammaproteobacteria Bacteria 7        
Asp6 hypothetical protein ACIAD0842 Acinetobacter sp. ADP1 267     50084055 Gammaproteobacteria Bacteria 8        
Sde1 protein of unknown function DUF81 Shewanella denitrificans OS217 264     91794131 Gammaproteobacteria Bacteria 8        
Vsp4 hypothetical protein VEx2w_02004048 Vibrio sp. Ex25 263     116183387 Gammaproteobacteria Bacteria 7        
Hpa1 hypothetical protein HPS_02594 Haemophilus parasuis 29755 264     167854629 Gammaproteobacteria Bacteria 8        
Hdu1 hypothetical protein HD0173 Haemophilus ducreyi 35000HP 263     33151424 Gammaproteobacteria Bacteria 8        
Tcr1 Protein of unknown function DUF81 Thiomicrospira crunogena XCL-2 268     78485755 Gammaproteobacteria Bacteria 8        
Lag2 hypothetical protein SIAM614_05471 Labrenzia aggregata IAM 12614 275     118593614 Alphaproteobacteria Bacteria 7        
Asa1 hypothetical integral membrane protein Aliivibrio salmonicida 279     16605593 Gammaproteobacteria Bacteria 9        
Pin2 hypothetical protein DUF81 Psychromonas ingrahamii 37 272     119946559 Gammaproteobacteria Bacteria 8        
Msp12 protein of unknown function DUF81 Magnetococcus sp. MC-1 265     117925601 Proteobacteria Bacteria 7        
Rsp19 membrane protein Roseovarius sp. HTCC2601 274     114764120 Alphaproteobacteria Bacteria 8        
Iba2 Predicted permease Idiomarina baltica OS145 264     85713215 Gammaproteobacteria Bacteria 8        
Ilo1 Predicted permease Idiomarina loihiensis L2TR 263     56459616 Gammaproteobacteria Bacteria 7        
Csp2 protein of unknown function DUF81 Cyanothece sp. PCC 7424 266     186901435 Cyanobacteria Bacteria 8        
Ama1 hypothetical protein AM1_3794 Acaryochloris marina MBIC11017 278     158336922 Cyanobacteria Bacteria 9        
                           
      total size ave. 253.8899           total TMSs ave. 7.68